#MOLECULAR SCAFFOLD MEANING SKIN#
#MOLECULAR SCAFFOLD MEANING ACTIVATOR#

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. RANK-L and RANK: T cells, bone loss, and mammalian evolution. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genetic regulation of osteoclast development and function. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures. Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis. Gu, H., Botelho, R.J., Yu, M., Grinstein, S. Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. Requirement of Gab2 for mast cell development and KitL/c-Kit signaling. Essential role for Gab2 in the allergic response. Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent.

#MOLECULAR SCAFFOLD MEANING SKIN#

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Essential role of Gab1 for signaling by the c-Met receptor in vivo. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Holgado-Madruga, M., Emlet, D.R., Moscatello, D.K., Godwin, A.K. Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Osteoclast differentiation and activation. Reaching a genetic and molecular understanding of skeletal development. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Molecular mechanisms of bone resorption: therapeutic implications. We have thus identified a new, key regulatory scaffold molecule, Gab2, that controls select RANK signaling pathways and is essential for osteoclastogenesis and bone homeostasis.īaron, R. We also show that Gab2 has a crucial role in the differentiation of human progenitor cells into osteoclasts. Inactivation of the gene encoding Gab2 in mice results in osteopetrosis and decreased bone resorption as a result of defective osteoclast differentiation. Here we report that the molecular adapter Grb-2-associated binder-2 (Gab2) associates with RANK and mediates RANK-induced activation of NF-κB, Akt and Jnk.

#MOLECULAR SCAFFOLD MEANING ACTIVATOR#

Receptor activator of NF-κB (RANK) and its ligand RANKL have been identified as essential factors involved in osteoclast development and bone remodeling, but their mechanism and interacting factors have not been fully characterized. Defective bone remodeling caused by altered osteoclast activity underlies a multitude of osteopenic disorders. Morphogenesis and remodeling of bone involve synthesis of bone matrix by osteoblasts and coordinate resorption of bone by osteoclasts.

Molecular scaffold meaning